Pep Guardiola may offer recalls to Phil Foden and Sergio Aguero after they did not start last weekend’s Manchester derby.
Manager Pep Guardiola could make changes following Sunday’s derby loss to Manchester United, which ended a 21-match winning run in all competitions.
Record goalscorer Sergio Aguero, an unused substitute in five of the last seven games, could be recalled along with Phil Foden, who has not started the last three.
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Southampton are without striker Danny Ings after he suffered a leg injury in Saturday’s victory over Sheffield United.
Manager Ralph Hasenhuttl has said the former Liverpool and Burnley forward is likely to be sidelined until next month.
Oriol Romeu, Theo Walcott, Michael Obafemi and Will Smallbone are also still absent.
Manchester City provisional squad: Ederson, Steffen, Cancelo, Walker, Stones, Dias, Laporte, Ake, Garcia, Zinchenko, Mendy, Gundogan, Fernandinho, Rodri, De Bruyne, Silva, Foden, Sterling, Torres, Mahrez, Jesus, Aguero.
Southampton provisional squad: Forster, McCarthy, Bertrand, Bednarek, Walker-Peters, Vestergaard, Minamino, Djenepo, Armstrong, Diallo, Ward-Prowse, Adams, Tella, Redmond, Salisu, N’Lundulu, Jankewitz, Chauke, Stephens, Watts, Ferry, Ramsay.
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